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HIV/AIDS is a complex retroviral infection that fundamentally alters the immune system's ability to defend the body, leading to a spectrum of health conditions if left untreated.

Core Mechanisms and Progression

  • HIV (Human Immunodeficiency Virus) attacks and destroys CD4 cells, a type of white blood cell crucial for immune function.
  • Without treatment, this leads to AIDS (Acquired Immunodeficiency Syndrome), the most advanced stage, characterized by a severely damaged immune system.
  • The progression from HIV to AIDS is now largely preventable with modern antiretroviral therapy (ART).

Modes of Transmission and Prevention

  • The virus is transmitted through specific bodily fluids: blood, semen, vaginal fluids, rectal fluids, and breast milk.
  • Effective prevention strategies include consistent condom use, Pre-Exposure Prophylaxis (PrEP) medication for at-risk individuals, and the use of sterile injection equipment.
  • Undetectable = Untransmittable (U=U): A person with HIV who is on effective treatment and maintains an undetectable viral load cannot sexually transmit the virus.

Modern Outlook and Management

  • HIV is now considered a manageable chronic health condition with proper, lifelong medical care.
  • Early testing and diagnosis are critical for initiating treatment and maintaining long-term health.
  • Ongoing research continues to advance treatment options and fuels the global pursuit of both therapeutic and preventive vaccines.