Active substance: Leucovorin calcium (chemically related to folic acid).
Class: Folic acid analogs.
Uses:
Methotrexate overdose and toxicity.
Preventing the harmful effects of methotrexate or similar medications.
Treatment of colorectal cancer (cancer that begins in the colon or rectum).
Treatment of anemia caused by low levels of folic acid in the body.
Contraindications:
Do not take if you are allergic to Leucovorin calcium, calcium folinate, or any other ingredients of this medicine.
Do not take if you have certain types of anemia (pernicious anemia or megaloblastic anemia) where vitamin B12 is deficient.
Consult your physician if you have anemia, kidney, heart, or liver problems.
Before starting treatment:
Inform your physician about all medications you are taking, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products.
Notify your physician if you are using any medications for treating seizures.
Inform your physician if you face any symptoms of wheezing or trouble breathing, skin rash, itching or hives, or swelling in the lips, face, or tongue.
Interaction with other drugs:
Certain medications may interact with the effects of Shilstine 50mg Injection and reduce its effectiveness by causing undesirable side effects.
Especially inform your physician if you are taking medications for seizures.
Storage:
Store Shilstine 50mg Injection in a refrigerator at 2° to 8°C.
Keep the injection away from the reach of children and pets.
Administration:
A trained physician or nurse in cancer chemotherapy will administer the drug to you.
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors.
The medicine is administered either intravenously (into your vein) or intramuscularly (into your muscle) based on your disease condition.
Safety advices:
Pregnancy: inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.
Breastfeeding: limited information is available on Shilstine 50mg Injection safety during breastfeeding.
Lungs: consult your doctor if you have any lung diseases before starting the treatment.
Liver: consult your doctor if you have any liver diseases before starting the treatment.
Alcohol: it is unknown whether it is safe to consume alcohol when taking Shilstine 50mg Injection. Consult your doctor for more advice.
Driving: it does not affect the ability to drive or operate heavy machinery after taking Shilstine 50mg Injection.
Side effects:
Common: diarrhea, nausea, vomiting, inflamed and sore mouth, tiredness.
Serious: allergic reactions.
Word of advice:
If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products.
Inform your doctor if you have vomited immediately after receiving the injection.
If you accidentally take too much Shilstine 50mg Injection, contact your doctor and seek medical advice immediately.
Do not stop taking this medicine unless your doctor tells you to.
Your doctor will regularly do lab tests to check the effectiveness of the medicine.
FAQs:
Why is Shilstine 50mg Injection given 24 hours after methotrexate?
Shilstine 50mg Injection is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.
Can Shilstine 50mg Injection cause swelling?
Shilstine 50mg Injection may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.
Can Shilstine 50mg Injection cause seizures?
There is no evidence that Shilstine 50mg Injection causes seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all your medicines, including over-the-counter medications.
How long does it take for Shilstine 50mg Injection to work?
Shilstine 50mg Injection starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.
What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Shilstine 50mg Injection?
Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion.
Monitoring the alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion.
Avoiding foods, drinks, and drugs that may increase urinary acidity during the therapy.
Measuring blood methotrexate concentration at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.
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