Cladrim 10mg injection is an antineoplastic drug belonging to the category of medicines known as purine analogues, containing the active ingredient Cladribine. It is used in the treatment of Multiple Sclerosis (is a type of autoimmune disorder that affects the nervous system). It is also used to treat Hairy cell leukaemia (cancer of white blood cells).
This drug is contraindicated in patients with current malignancies, active chronic infections like tuberculosis or hepatitis, and for those with a history of hypersensitivity reactions. High doses of this drug have been associated with the irreversible neurologic toxicity (paraparesis/quadriparesis), acute nephrotoxicity, and severe bone marrow suppression resulting in neutropenia, anaemia and thrombocytopenia. Clinicians should also monitor patients frequently for signs and symptoms of neurological impairment, such as numbness or tingling in the arms or legs, weakness, or loss of bowel or bladder control. If these symptoms occur, urgent treatment is necessary to prevent further neurological damage. It is essential to inform your doctor if you have a history of any bleeding disorders, liver or kidney disease, or if you're taking any other medications, including over-the-counter drugs, supplements, or herbal remedies.
Consult your doctor before using this medication if you are pregnant or plan to have a baby. This medicine is not recommended for pregnant women as it may cause fetal harm. Your health care practitioner will conduct a pregnancy test before you start treatment with this Injection. This medicine may cause birth defects if either partner uses it during conception or pregnancy. Male patients with female partners of reproductive potential should use effective birth control during the treatment and for 3 months after the last dose. Do not breastfeed during the treatment and for 10 days after the last dose. Avoid vaccination with live-attenuated or live vaccines during and after the treatment with this drug while the patient’s white blood cell counts are not within normal limits.
Uses of Cladrim 10mg InjectionMultiple sclerosisHairy cell leukaemia Therapeutic Effects of Cladrim 10mg Injection
It is a purine analog drug, which means it mimics the structure of purines (the building blocks of DNA). When this drug binds into the DNA of cancer cells, it interferes with DNA synthesis and repair, leading to the accumulation of damaged DNA and leads to cell death. Interaction of Cladrim 10mg Injection with other drugsInform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Cladrim 10mg injection and reduce effectiveness by causing undesirable side effects.More Information about Cladrim 10mg Injection Store Cladrim 10mg injection in a refrigerator at (2°C to 8°C).Keep it out of reach from children.How to consume Cladrim 10mg InjectionIt should only be administered by a trained doctor or nurse experienced in giving chemotherapy. This drug can be administered either as an intravenous (IV) infusion or as a subcutaneous injection. When given as an IV infusion, the drug is administered over a period of two hours. When given as a subcutaneous injection, the drug is administered under the skin using a small needle. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors.Safety Advices for Cladrim 10mg Injection
Pregnancy
Cladrim 10mg injection is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Breast Feeding
It is not known if Cladrim 10mg injection passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.
Lungs
Inform your doctor if you have any lung problems before taking Cladrim 10mg injection.
Liver
It is unsafe to use Cladrim 10mg injection in severe liver failure patients. Dose adjustments are required in severe hepatic impairment. Consult your physician if you have any liver diseases.
Alcohol
It is unknown whether consuming alcohol while taking Cladrim 10mg injection is safe. Please speak with your physician.
Driving
It is not known whether Cladrim 10mg injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Side Effects of Cladrim 10mg InjectionSide effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Serious
- Septic shock (infection throughout the body)
- Malignancies
- Anemia
- Renal failure
- Bleeding
- Depressed level of consciousness
- Neurotoxicity
- Infection
Common
- Low white blood cells
- Allergic reactions
- Administration site reaction
- Confusion, Anxiety, Insomnia
- Headache, dizziness
- Eye infection
- Abnormal heart rate
- Cough, abnormal breath sounds
- Nausea, vomiting
- Abdominal pain, constipation, diarrhea
- Buildup of gas
- Rash, itchiness
- Chills
- Loss of appetite
- Pain, joint pain
- Fatigue, muscle weakness
- Swelling in the hands and feet
- Inflammation of vein
Word of AdviceAvoid contact with people who have infections, especially during the time when you are taking the medication. Limit direct skin contact with the tablets, and wash exposed areas thoroughly. Your doctor will perform regular blood tests during treatment with this drug to monitor the blood cell counts and kidney function. Let your doctor know about any other medications you are taking, including over-the-counter drugs, supplements, or herbal remedies.FAQs Q 1. Who cannot take Cladrim 10mg injection?Cladrim 10mg injection is primarily eliminated from the body through the kidneys. People with severe kidney impairment may not be able to eliminate the drug effectively, which can increase the risk of side effects. Therefore, those who have kidney disease should talk with your doctor before taking this tablet.
Q 2. What are the warnings of Cladrim 10mg injection?Patients with severe kidney impairment may not be able to eliminate the drug effectively, which can increase the risk of side effects. Dose adjustments may be necessary for patients with kidney impairment.
Q 3. Whether Cladrim 10mg injection causes any neurologic events?Yes, Cladrim 10mg injection can cause neurologic events, such as seizures and neuropathy. Patients should be monitored for signs of neurologic events and inform their healthcare provider if they experience any.
Q 4. What is the dosing frequency for Cladrim 10mg injection?The recommended dosing of Cladrim 10mg injection is usually 0.09 mg/kg given over a 2-hour intravenous infusion on days 1 and 2 of a 7-day treatment cycle, with cycles repeated every 4 weeks for a total of 6 cycles.
Q 5. How do you store Cladrim 10mg injection?Cladrim 10mg injection should be stored in a refrigerator at a temperature of 2°C to 8°C. Do not freeze the medication.
Fact Box of Cladrim 10mg InjectionMolecule name: Cladribine | Therapeutic class: Antineoplastics |
Pharmacological class: Purine analogues | Indications: 1.Multiple sclerosis 2.Hairy cell leukaemia
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