Decreasing the risk of developing febrile neutropenia (occurrence of fever or infection with low WBC count) and the duration of neutropenia (low white blood cell count) when receiving bone marrow-suppressive chemotherapy drugs.
Increasing survival rate in patients exposed to radiation therapy which can cause severe and life-threatening damage to bone marrow.
Mechanism of action:
Acts on blood-forming cells, stimulating cell multiplication and cell function activation.
Pegfilgrastim is a protein synthesized through biotechnology in E. coli bacteria. It belongs to the cytokine family of proteins and is very similar to a natural protein (granulocyte-colony stimulating factor) produced by your body.
Indications:
Decrease the chance of infection caused by low levels of white blood cells in patients with certain types of cancer (non-myeloid) receiving bone marrow-suppressing anti-cancer drugs.
Increase the survival rate in patients receiving radiation therapy that suppresses bone marrow activity.
Important information:
Inform your physician if you have or ever had liver disease, fever or infection, kidney problems, heart problems, or a family history of kidney diseases before starting the treatment with this Injection.
Do not take this Injection if you are allergic to pegfilgrastim, filgrastim, or any of the other ingredients in this Injection.
Report any symptoms of left upper abdominal pain, shoulder pain, and respiratory problems immediately to your doctor.
Side effects:
Common: pain in the bones, joints and muscles, pain at the site of Injection, itchiness and skin rash, nausea, headaches, dizziness and tiredness.
Serious: inflammation of the aorta, capillary leak syndrome (plasma leaks out of tiny blood vessels), hypersensitivity reactions, changes in urine color, swelling in hands, feet, face, and abdomen, difficulty in breathing, sickle cell anemia.
Safety advice:
Pregnancy: unsafe when administered during pregnancy because it may cause birth defects in your baby.
Breastfeeding: unsafe to breastfeed during the treatment with this Pegex 6mg Injection because it may cause harm to the baby.
Lungs: it is unknown whether Pegex 6mg Injection can be administered to patients with lung problems.
Liver: it is unknown whether Pegex 6mg Injection can be administered in patients with liver disorders.
Alcohol: unsafe to consume alcohol with Pegex 6mg Injection.
Driving: unsafe to travel, drive vehicles or operate heavy machinery after taking (1 hour) Pegex 6mg Injection.
Storage:
Store Pegex 6mg Injection in a refrigerator (2°C – 8°C). Do not freeze.
Do not shake this Injection.
Discard the Injection if it has been stored at room temperature for more than 48 hours.
Keep it out of reach from children and pets.
Administration:
The Injection will be administered in the fatty tissues just under your skin (subcutaneously) by a qualified healthcare professional in a hospital setting.
The dose and frequency of administration will be decided by your doctor based on your disease condition and other factors.
If your physician decides that Pegex 6mg Injection can be administered at home by you or your caregiver, then read the "Instructions for use" carefully from the package insert that comes with the Injection.
FAQs:
What is the difference between Pegex 6mg Injection pre-filled syringe and on-body injector?
The on-body injector is a small, lightweight delivery system applied to the skin during your chemo appointment. It is automatically designed to inject the dose under your skin (subcutaneously) whereas the pre-filled syringe contains the Pegex 6mg Injection medicine, and it should be injected by your healthcare provider or you manually.
What are the symptoms that I should notify the physician when taking Pegex 6mg Injection?
Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes.
What is the Pegex 6mg Injection package insert?
The FDA provides a package insert, which summarizes the relevant scientific information needed for healthcare practitioners and patients to use the drug safely and effectively. The package insert contains safety information, instruction for use, and other information.
Who should not take Pegex 6mg Injection?
Pegex 6mg Injection is not indicated for everyone. Do not take this Injection if you are allergic to pegfilgrastim, filgrastim, or any of the other ingredients in this Injection.
Will Pegex 6mg Injection affect my kidneys?
This Injection may affect your kidneys. Regular kidney function tests will be taken to monitor your kidney functions. Inform your physician if you have any kidney problems.
Can I breastfeed while taking Pegex 6mg Injection?
No, this Injection secretes in small amounts in breast milk. Pegex 6mg Injection can cause harm to your baby. Please consult your doctor if you are breastfeeding.
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