Active component: deferoxamine.
Indications:
- Thalassemia;
- Hemochromatosis;
- Sickle cell disease;
- Myelodysplastic syndromes;
- Chronic transfusions;
- Iron poisoning.
Mechanism of action:
- Chelation: the drug binds to excess iron in the body, forming stable complexes with free iron ions.
- The complexes are excreted through urine, removing excess iron from the bloodstream and tissues.
- Reduces iron levels, preventing iron-related oxidative damage to organs and tissues.
Administration:
- Administered in a hospital or clinical setting by healthcare professionals.
- Dosage and administration depend on the treatment condition and healthcare provider's instructions.
Safety advice:
- Pregnancy: use with caution and only after consulting a healthcare provider.
- Breastfeeding: the safety in breastfeeding has not been established.
- Lungs: generally safe for individuals with normal lung function. Caution in patients with pre-existing lung conditions.
- Liver: generally safe for individuals with normal liver function. Caution in patients with pre-existing liver conditions.
- Alcohol: combining Desferal 500mg Injection and alcohol may increase the risk of liver damage.
- Driving: avoid driving or operating heavy machinery if experiencing dizziness, headache, or visual disturbances.
Side effects:
- Serious: chest tightness with wheezing or coughing, allergic reactions, decreased urine output, seizures, infections.
- Common: pain, swelling, redness, and itching at the injection site, headache, reddish-brown urine, nausea, fever, slow growth in children under age three.
Precautions:
- Inform healthcare provider about pre-existing medical conditions, allergies, or medications.
- Regular monitoring of iron levels, kidney function, and blood counts is crucial.
- Abrupt discontinuation may lead to a rebound increase in iron levels.
- Pregnant or breastfeeding individuals should discuss potential risks with healthcare provider.
FAQs:
What are the common side effects of Desferal 500mg Injection? Common side effects may include gastrointestinal disturbances (nausea, vomiting, diarrhea), injection site reactions, dizziness, and headache.
Can Desferal 500mg Injection cause kidney problems? Desferal 500mg Injection may affect kidney function in some patients, especially those with pre-existing kidney problems. Regular monitoring is essential.
Is Desferal 500mg Injection safe for children? Desferal 500mg Injection is generally well-tolerated in children, but appropriate dosage and monitoring are crucial.
How long is Desferal 500mg Injection treatment usually required? The duration depends on the severity of iron overload and the patient's response to therapy. Some individuals may require lifelong treatment.
Can Desferal 500mg Injection lead to iron deficiency? While used to treat iron overload, it may also lead to iron deficiency if not appropriately managed. Regular monitoring of iron levels is necessary.
Can Desferal 500mg Injection cause changes in vision or hearing? Yes, Desferal 500mg Injection may cause visual and auditory disturbances in some individuals.
Storage:
- Store at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- Do not freeze.
- Keep away from children and pets.