Uses of Mabtas 500mg Injection
- Non-Hodgkin’s lymphoma (NHL)
- Chronic lymphocytic leukemia (CLL)
- Rheumatoid arthritis
- Granulomatosis with polyangiitis or microscopic polyangiitis
- Pemphigus vulgaris
Therapeutic Effects
Mabtas 500mg injection is a monoclonal antibody that targets the antigen CD20 expressed on the cell surface of B-lymphocytes. It induces cell death in NHL and CLL, blocks cell activation and growth, and inhibits rheumatoid factor production, antigen presentation, T-cell activation, and proinflammatory cytokine production in rheumatoid arthritis.
Interaction with Other Drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Mabtas 500mg injection and reduce its effectiveness or cause undesirable side effects.
Safety Advice
- Pregnancy: Mabtas 500mg injection is unsafe to administer in pregnant women because it may affect the fetus.
- Breastfeeding: Breastfeeding is not recommended in patients taking Mabtas 500mg injection.
- Lungs: Consult your doctor if you have any lung diseases before starting the treatment.
- Liver: Consult your doctor if you have or ever had liver disease or hepatitis B infection before starting the treatment.
- Alcohol: Stop consuming alcohol if you are taking this medicine.
- Driving: Caution is required while driving and operating machinery when you take Mabtas 500mg injection because it may cause dizziness, sleepiness, tiredness, and risk of falling.
Side Effects
Common side effects:
- Swelling in the face and body
- Diarrhea and nausea
- Itchy skin
- Anemia
- Muscle spasm
- Headache
- Urinary tract infection
- Fever, chills, and shivering
- Inflammation of nasal cavities
- Cough, sore throat
- Loss of hair
Serious side effects:
- Increased or decreased blood pressure
- Chest pain
- Hypersensitivity reactions
- Hepatitis B viral infection
- Memory loss, trouble thinking, difficulty in walking
FAQs
Q 1. What are the special precautions I should be aware of before starting treatment with Mabtas 500mg injection?
Inform your doctor about your pre-existing conditions (heart, kidney, liver, hepatitis B, or lung disease) and vaccination history. It is necessary to consult a doctor if you are taking medicines for blood pressure.
Q 2. What are Mabtas 500mg infusion-related reactions?
Infusion reactions occur during or within 24 hours after administering Mabtas 500mg injection. The symptoms are fever, chills, cough, itchy skin, nausea, vomiting, flushing, increased heart rate, and discomfort in the throat. Inform your physician immediately if you face any infusion-related reaction.
Q 3. What will be the most important thing to monitor during Mabtas 500mg injection?
Your healthcare professional will monitor you carefully for unwanted side effects during the Mabtas 500mg injection. You will be monitored for heart failure, increased blood pressure, or breathing failure.
Q 4. Is weight gain a side effect of Mabtas 500mg injection?
Weight gain has been reported in patients treated with Mabtas 500mg injection for non-Hodgkin’s lymphoma.
Q 5. Does Mabtas 500mg injection suppress the immune system?
Yes, Mabtas 500mg injection can suppress the immune system, and the chances of catching an infection are high. Inform your doctor if you have a severe active infection before taking Mabtas 500mg injection because it may cause drug-induced immunosuppression.
Fact Box
- Molecule name: Rituximab
- Therapeutic class: Antineoplastics, DMARDs
- Pharmacological class: Anti-CD20 monoclonal antibodies
- Indications: Non-Hodgkin's lymphoma, chronic lymphocytic leukemia (CLL), rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis, pemphigus vulgaris