A white blood cell growth factor (granulocyte-colony stimulating factor).
Approved by the FDA to decrease the risk of developing febrile neutropenia and to reduce the duration of neutropenia in people receiving chemotherapy drugs.
Used to increase the number of WBC and decrease the length of time of fever in people with acute myeloid leukemia.
Also used in people undergoing bone marrow transplants and in people with severe chronic neutropenia.
Uses:
To prevent infections after chemotherapy due to decreased white blood cells (neutropenia).
To prepare the blood for leukapheresis.
To increase the chance of survival in people exposed to harmful amounts of radiation.
Other uses include in patients with advanced HIV infection.
Therapeutic Effects:
Acts on blood-forming cells by binding to specific cell surface receptors, thereby inducing cell division, multiplication, and cell functional activation.
Interaction with other drugs:
Inform your healthcare provider about all the medicines you take.
Certain medications may interact with Lupifil 300mcg injection and reduce effectiveness by causing undesirable side effects.
Storage:
Store Lupifil 300mcg injection in a refrigerator (2°C – 8°C). Do not freeze.
Do not shake the pre-filled syringe.
Discard the medicine if stored at room temperature for more than 48 hours.
Keep it out of reach from children and pets.
Administration:
Available as a prefilled syringe and solution for injection.
Administered subcutaneously (in the fatty tissues just under the skin) or intravenously (into the vein) slowly.
The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors.
If you or your caregiver can administer the injection at home, read the “Instructions for use” carefully from the package insert with the medicine.
Safety Advices:
Pregnancy: unsafe when administered during pregnancy because it may cause birth defects in your baby.
Breastfeeding: unsafe to breastfeed during the treatment.
Lungs: it is unknown whether Lupifil 300mcg injection can be administered to patients with lung problems.
Liver: it is unknown whether Lupifil 300mcg injection can be administered in patients with liver disorders.
Alcohol: it is unsafe to consume alcohol with Lupifil 300mcg injection.
Driving: it is unsafe to travel, drive vehicles, or operate heavy machinery after taking (1 hour) Lupifil 300mcg injection pre-filled injection.
Side Effects:
Common: pain in the bones, joints, and muscles, pain at the site of injection, fever, itchiness and skin rash, nausea, headaches, dizziness and tiredness, nose bleeding, hair fall.
Serious: inflammation of aorta, capillary leak syndrome, hypersensitivity reactions, changes in urine color, swelling in hands, feet, face, and abdomen, difficulty in breathing, sickle cell anemia.
Word of Advice:
Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes.
If you use the prefilled syringe, allow the medicine to warm for 30 minutes at room temperature before injecting.
Read the package insert carefully if you are self-administering the medicine.
This medicine may cause lung, liver, or kidney problems. Your physician may advise you to take laboratory tests regularly to monitor the effectiveness of the therapy.
FAQs:
What are the symptoms that I should notify the physician while taking Lupifil 300mcg injection?
Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes.
What is the Lupifil 300mcg injection package insert?
The FDA provides a package insert, which summarizes the relevant scientific information needed for healthcare practitioners and patients to use the drug safely and effectively. The package insert contains safety information, instruction for use, and other information.
Who should not take Lupifil 300mcg injection?
Lupifil 300mcg injection is not indicated for everyone. Do not take this medicine if you are allergic to any forms of rubber, latex, pegfilgrastim, filgrastim or any of the other ingredients in this medicine.
Will Lupifil 300mcg injection affect my kidneys?
This medicine may affect your kidneys. Regular kidney function tests will be taken to monitor your kidney functions. Inform your physician if you have any kidney problems.
Can I breastfeed while taking Lupifil 300mcg injection?
No, this medicine secretes in small amounts in breast milk. Lupifil 300mcg injection can cause harm to your baby. Please consult your doctor if you are breastfeeding.
