Knilonat 150mg Capsule: Effective Relief for Your Condition

Uses of Knilonat 150mg Capsule

• Treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph-positive CML) in adults and pediatric patients, including newly diagnosed cases and those with side effects from previous treatment.
• Used in patients no longer responding to previous treatment, including Imatinib.

Therapeutic Effects

• Disrupts the signaling route of the BCR-ABL tyrosine kinase protein, inhibiting the growth and spread of cancer cells.

Interaction with Other Drugs

• Inform your healthcare professional about all medications, including prescription, over-the-counter, nutritional supplements, and herbal products.
• Avoid interactions with antiarrhythmics, chloroquine, Titonavir, Carbamazepine, and other drugs that may reduce effectiveness or cause undesirable side effects.

Safety Advice

• Pregnancy: unsafe to use during pregnancy unless necessary. Consult your doctor if pregnant or planning pregnancy.
• Breastfeeding: may affect the child. Consult your doctor for more information.
• Lungs: consult your doctor if you have lung conditions.
• Liver: use cautiously with liver problems. Liver function tests are conducted before starting treatment.
• Alcohol: unknown whether consuming alcohol is safe. Consult your physician.
• Driving: unsafe to drive or use machines due to potential side effects like nausea and vomiting.

Side Effects

• Serious: sudden weight gain, swelling in hands, feet, ankles, or face, chest pain, blood pressure changes, discoloration of tongue, lips, or skin (blue), abnormal heart rhythm, hair loss, vision problems, stomach pain, vomiting of blood, blood in stools, yellowing of the skin, eyes, and dark urine, high blood sugar levels, sensitivity to light.
• Common: nausea, vomiting, diarrhoea, headache, muscle pain, stomach pain, tiredness, constipation, slowing growth in children, pneumonia, loss of appetite, sleeplessness, depression, anxiety, stomach discomforts like bloating and flatulence after meals, musculoskeletal pain.

Word of Advice

• Based on your condition, your doctor may prescribe a lower dose.
• Knilonat 150mg capsule can be used by people aged 65 years and over with the same dose as other adults.
• Report any irregular heartbeats or signs of a heart condition to your doctor.
• Inform your physician if you have kidney problems.
• Some children and adolescents may have slower than normal growth.
• Report a history of heart failure or hepatitis infection to your doctor.

FAQs

• Q1. Can Knilonat 150mg capsule cause liver damage? Knilonat 150mg capsule may cause liver function abnormalities. Regular blood tests are important to monitor liver function.

• Q2. How does Knilonat 150mg capsule differ from other medications used to treat chronic myeloid leukemia, such as Imatinib? Knilonat 150mg capsule is more selective for the BCR-ABL protein and more potent in inhibiting its activity. It is effective in patients who have developed resistance to Imatinib.

• Q3. What are the potential long-term effects of Knilonat 150mg capsule on the body? Potential long-term effects include cardiovascular events, liver dysfunction, pancreatic enzyme elevation, and fluid retention. These side effects are generally rare.

• Q4. How to monitor the effects of Knilonat 150mg capsule over the course of treatment? Monitor through regular blood tests, electrocardiograms, and imaging studies. Blood tests assess liver and kidney function, blood counts, and electrolyte levels. ECG detects changes in heart rhythm or function. Imaging studies evaluate the heart and lungs.

• Q5. Who should not take Knilonat 150mg capsule? Knilonat 150mg capsule should not be taken by pregnant or breastfeeding women, or by people with severe liver or kidney disease, a history of pancreatitis, or a prolonged QT interval.

Fact Box

• Molecule name: Nilotinib
• Therapeutic class: Antineoplastic drug
• Pharmacological class: Tyrosine Kinase inhibitors
• Indications: Blood cancer (Philadelphia chromosome-positive chronic myeloid leukemia) in adults and pediatrics.

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