Velcade 3.5mg injection is a chemotherapeutic medication that belongs to the class of drugs called Proteasome inhibitors. It contains the active compound Velcade 3.5mg injection. It is used to treat multiple myeloma and mantle cell lymphoma. This medication is concomitantly used with other chemotherapy medicines like pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone or thalidomide for patients who have not started treatment and are unsuccessful or ineligible for blood stem cell transplant treatment.
It is not recommended to take Velcade 3.5mg injection if you are allergic to active compounds or any other ingredients of this medicine. It is not advised to take this medicine if you have a compromised immune system. If you have an active infection, let your doctor know before beginning any treatment. It is not recommended to use Velcade 3.5mg injection in childrens and adolescents. It is not recommended to use this medication in patients with hepatitis. Inform your doctor if you have gastrointestinal disorders, hepatic disorders, thrombocytopenia (low platelet count), neutropenia (low white blood cell count), tumor lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), neuropathy (nerve malfunction), cardiac disorders, severe lung problems, pulmonary disorders and posterior reversible encephalopathy syndrome disorders before beginning the treatment with this medication. You are advised to monitor blood counts and hepatic enzymes throughout the treatment period.
The use of Velcade 3.5mg injection during pregnancy and breastfeeding is not recommended and will be determined by the doctor only if absolutely necessary as it may cause harm to the developing foetus. It is recommended to use effective contraceptive methods during the therapy and 3 months after completion. Inform your doctor if you are pregnant or planning to get pregnant to know about effective contraceptive methods. It is necessary to inform your physician about all the medicines, over the counter drugs, vitamin and herbal supplements you are taking before the start of therapy.
Uses of Velcade 3.5mg InjectionTreatment of multiple myelomaTreatment of mantle cell lymphoma Therapeutic Effects of Velcade 3.5mg Injection
Velcade 3.5mg injection works by exerting a toxic effect on cancer cells. It inhibits the 26S proteasome and blocks a major cell signaling pathway. This inhibition of the signaling pathway makes the cancer cells sensitive to chemotherapy. By inhibiting the proteasome, Velcade 3.5mg injection disrupts the normal process of protein degradation within the cell. This leads to the accumulation of misfolded or damaged proteins, which are toxic to the cell. The accumulation of misfolded proteins triggers a series of cellular responses, including the activation of stress pathways and the induction of apoptosis. This medicine also enhances the build-up of a protein and minimizes cancer cell growth and multiplication. Interaction of Velcade 3.5mg Injection with other drugsInform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Velcade 3.5mg injection and reduce effectiveness by causing undesirable side effects.More Information about Velcade 3.5mg Injection Store in a refrigerator (2°C – 8°C).Do not freeze.Protect the medicine from light and excessive moisture.Keep the medicine out of reach of children and petsIt is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.How to consume Velcade 3.5mg InjectionVelcade 3.5mg injection is administered by injection intravenously in your vein or subcutaneously under the skin. It is given in by a healthcare professional in a hospital setting. The dosage and frequency of Velcade 3.5mg injection will depend on various factors, including the patient's age, weight, overall health, and the type and stage of disease being treated. It's important to follow the dosing instructions provided by a healthcare provider, and not to adjust the dosage or frequency without consulting with them first. Do not self-administer this injection. If a dose is missed, it should be taken as soon as possible unless it's within 6 hours of the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. It's important not to take a double dose of Velcade 3.5mg injection to make up for a missed dose.Safety Advices for Velcade 3.5mg Injection
Pregnancy
Velcade 3.5mg injection should not be taken while pregnant unless prescribed by a physician. Your physician will prescribe it only if necessary on an individual case to case basis. Inform your physician if you are pregnant, suspecting, or planning to get pregnant during the treatment. Use effective contraception during the treatment and for at least 3 months after the last dose.
Breast Feeding
It is not recommended to use Velcade 3.5mg injection during breastfeeding. Your physician will prescribe it only if necessary. You should consult your physician regarding the safe period to restart breastfeeding after this treatment.
Lungs
Velcade 3.5mg injection should be used with caution in individuals who have respiratory issues. Let your doctor know if you have any lung conditions before starting any treatment.
Liver
Velcade 3.5mg injection should be taken cautiously in patients with liver problems. If you have liver disease or an infection with hepatitis, let your doctor know before beginning this treatment. Your doctor will periodically check on the health of your liver.
Alcohol
Velcade 3.5mg injection is metabolized in the liver, and excessive alcohol consumption can also lead to liver damage. The use of two concomitantly may potentially increase the risk of liver problems.
Driving
Velcade 3.5mg injection may impair your ability to operate machinery, ride a bike, or drive. After taking this medication,tiredness, dizziness and blurred vision are expected.If a patient experiences any side effects that affect their ability to drive or operate machinery safely while taking Velcade 3.5mg injection , they should avoid these activities and seek medical advice.
Side Effects of Velcade 3.5mg InjectionSide effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Serious:
- Peripheral neuropathy
- Hypotension
- Cardiac toxicity
- Posterior Reversible Encephalopathy Syndrome (PRES)
- Tumor Lysis Syndrome
- Hepatic Toxicity
- Thrombotic Microangiopathy
Common:
- Loss of appetite
- Sensitivity, tingling and burning sensation of the skin
- Nausea, vomiting, and diarrhea
- Mouth ulcers
- Constipation
- Muscle and bone pain
- Hair loss
- Fever
- Reduction in blood cell count
- Reduced kidney function
- Shivering
- Infections
- Dehydration
- Stomach problems
- Difficulty sleeping, anxiety, mood swings, depressed mood
Word of AdviceIf you have been prescribed Velcade 3.5mg injection it is important to follow the instructions provided by your healthcare provider and to report any side effects or concerns promptly. Even if you feel better or see a change in your symptoms, you should still talk to your doctor before stopping Velcade 3.5mg injection. It is advised that both men and women must use an effective contraception method during treatment and three months afterward. Treatment with Velcade 3.5mg injection can commonly cause a decrease in the number of red and white blood cells and platelets in your blood. Therefore, you will have to take regular blood tests before and during your treatment with Velcade 3.5mg injection to check your blood cell counts regularly. Include anti-inflammatory foods in your diet, such as olive oil, nuts, seeds, fruits, vegetables, and fatty fish. Include foods like avocados, almonds, seeds, and olive oil in your diet as sources of healthful fats. These fats can improve general health by lowering inflammation. To stay hydrated, sip lots of water throughout the day. Monitor your blood sugar level frequently If you are taking antidiabetic medication and report to your physician if you notice any fluctuations in your blood sugar levels.Consult your physician before getting any vaccinations because certain of them can make you sick and should not be administered while you are on this medication. If you currently have or have ever had hepatitis B, let your doctor know. Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately.
FAQs Q 1. I have an infection with hepatitis. Is Velcade 3.5mg injection safe to take?Patients with active hepatitis should not take boratezamib. because they may experience recurrent, potentially fatal cases of hepatitis. Your doctor will closely monitor you for signs of active hepatitis B if you have a history of the infection.
Q 2. Can I take Velcade 3.5mg injection when I am pregnant?Avoid taking Velcade 3.5mg injection if you are pregnant, as it can cause harmful effects on the unborn baby. Females should use effective birth control methods during treatment and at least three months after treatment.
Q 3. What are the common side effects of Velcade 3.5mg injection?Common side effects of adalimumab may include injection site reactions, such as pain, redness, or swelling. Other possible side effects include loss of appetite, sensitivity, tingling and burning sensation of the skin, nausea, vomiting, and diarrhea, constipation Serious side effects are rare but can occur.
Q 4. How long can I take Velcade 3.5mg injection?The duration of Velcade 3.5mg injection treatment can vary depending on the individual's condition and response to the medication. In some cases, this medicine may be used as a long-term maintenance therapy, while treatment duration may be shorter in other situations. It is important to follow the healthcare provider's guidance regarding the appropriate duration of treatment.
Q 5. Can Velcade 3.5mg injection be used in individuals with kidney or liver impairment?Velcade 3.5mg injection may require dosage adjustments or caution in individuals with kidney or liver impairment. Healthcare providers will assess the patient's situation and determine the appropriate dosage based on renal and hepatic function.
Q 6. What parameters will be monitored during treatment with Velcade 3.5mg injection?During treatment with Velcade 3.5mg injection, your health care provider will monitor RBC, WBC, platelets, liver, blood glucose and kidney parameters.
Fact Box of Velcade 3.5mg InjectionMolecule name: Bortezomib | Therapeutic class: Antineoplastic agents |
Pharmacological class: Proteasome inhibitors | Indications: 1. Treatment of multiple myeloma 2. Treatment of mantle cell lymphoma |
Dosage form: Injections | Habit forming: No |
