Uses:
- Rheumatoid arthritis (a condition in which the body attacks its joints, causing pain, swelling, and loss of function).
- Psoriatic arthritis (a condition that causes joint pain and swelling, and scales on the skin).
- Ankylosing spondylitis (inflammatory disease of the spine).
- Ulcerative colitis (a condition affecting the colon and rectum).
- Polyarticular juvenile idiopathic arthritis (a long-term disease mainly causing pain and swelling of your joints in patients 2 years of age and older).
- Juvenile psoriatic arthritis.
Therapeutic Effects:
- Jakauto 2% Gel is a disease-modifying anti-rheumatic drug (DMARD) belonging to the category of Janus Kinase Inhibitors.
- It works by inhibiting Janus kinases, interfering with the transcription of genes involved in cell growth and differentiation.
Interaction with Other Drugs:
- Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products.
- Certain medications may interact with the effects of tofacitinib and reduce its effectiveness or cause undesirable side effects.
Safety Advice:
- Pregnancy: Jakauto 2% Gel is unsafe to administer in pregnant women because it may affect the fetus.
- Breastfeeding: Breastfeeding is not recommended in patients taking Jakauto 2% Gel.
- Lungs: Consult your doctor if you have any lung diseases before starting the treatment.
- Liver: Jakauto 2% Gel is unsafe when administered in patients with severe liver diseases.
- Alcohol: It is unknown whether it is safe to consume alcohol when taking Jakauto 2% Gel. Consult your doctor for more advice.
- Driving: The drug has no or limited effect on your ability to drive or operate heavy machines.
Side Effects:
- Common: increased cholesterol levels, headache, painful urination, inflammation of the nose, cough, shortness of breath, diarrhea, skin rashes.
- Serious: lung cancer, white blood cell cancer, heart attack, fever and chills, blood in the stool, stomach pain or abdominal pain, skin blisters.
Word of Advice:
- This medicine may interfere with vaccines, inform your physician about all your vaccination history.
- This medicine may impair fertility; talk to your doctor before taking this medicine.
- Your doctor will regularly do lab tests to check whether the medicine is working.
- Do not breastfeed during the treatment with this medicine and for at least 36 hours after your last dose.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury.
FAQs:
What are the cautions of Jakauto 2% gel? Tell your doctor immediately if you start to have swelling of your face, lips, tongue, throat, arms, or legs or if you are having trouble swallowing or breathing. Jakauto 2% gel can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection.
Does Jakauto 2% gel cause high cholesterol? Increased cholesterol levels are one of the side effects of Jakauto 2% gel. Your doctor may take regular blood tests to check for serious side effects.
Can Jakauto 2% gel cause depression? No, Jakauto 2% gel does not cause depression. However, many people who have autoimmune conditions also have symptoms of depression. If you're having symptoms of depression, see your doctor right away.
Does Jakauto 2% gel cause blood clots? Yes, blood clots are reported in patients using Jakauto 2% gel for a longer period. Inform your physician if you face any symptoms of a blood clot.
How long does it take Jakauto 2% gel to work? Jakauto 2% gel is a long-term treatment. Most people who benefit from this treatment will notice an improvement in the first 12 weeks of starting treatment.
Fact Box:
- Molecule name: Tofacitinib.
- Therapeutic class: Antineoplastics.
- Pharmacological class: Tyrosine kinase inhibitor.
- Indications: Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, polyarticular juvenile idiopathic arthritis, juvenile psoriatic arthritis.