Imupeg 6mg Injection
Active ingredient: Pegfilgrastim
Class: Granulocyte colony-stimulated factor
FDA approval: To decrease the risk of developing febrile neutropenia (occurrence of fever or infection with low WBC count) and the duration of neutropenia (low white blood cell count) when receiving bone marrow suppressive chemotherapy drugs. Also indicated to increase survival rate in patients exposed to radiation therapy.
Mechanism of action: Pegfilgrastim acts on blood-forming cells, stimulating cell multiplication and activation of cell function. It is a protein synthesized through biotechnology in E. coli bacteria and is similar to a natural protein produced by the body.
Uses:
- Decrease the chance of infection caused by low levels of white blood cells in patients with certain types of cancer (non-myeloid) receiving bone marrow suppressing anti-cancer drugs.
- Increase the survival rate in patients receiving radiation therapy that suppresses bone marrow activity.
Important information:
- Inform your physician if you have or ever had liver disease, fever or infection, kidney problems, heart problems, or a family history of kidney diseases before starting treatment.
- Do not take this injection if you are allergic to pegfilgrastim, filgrastim, or any of the other ingredients in this injection.
- Report any symptoms of left upper abdominal pain, shoulder pain, and respiratory problems immediately to your doctor.
Common side effects:
- Pain in the bones, arms, and legs.
- Itchiness and skin rash.
- Nausea.
- Headaches.
- Dizziness and tiredness.
Serious side effects:
- Inflammation of the aorta.
- Capillary leak syndrome (plasma leaks out of tiny blood vessels).
- Hypersensitivity reactions.
- Changes in urine color.
- Swelling in hands, feet, face, and abdomen.
- Difficulty in breathing.
- Sickle cell anemia.
Pregnancy and breastfeeding:
- Imupeg 6mg Injection is unsafe when administered during pregnancy because it may cause birth defects in your baby.
- It is unsafe to breastfeed during treatment with this injection because it may cause harm to the baby.
Driving and operating machinery:
- It is unsafe to travel, drive vehicles, or operate heavy machinery after taking (1 hour) Imupeg 6mg Injection.
Storage:
- Store Imupeg 6mg Injection in a refrigerator (2°C – 8°C). Do not freeze.
- Do not shake this injection.
- Discard the injection if it has been stored at room temperature for more than 48 hours.
- Keep it out of reach from children and pets.
Administration:
- The injection will be administered in the fatty tissues just under your skin (subcutaneously) by a qualified healthcare professional in a hospital setting.
- If your physician decides that Imupeg 6mg Injection can be administered at home, read the "Instructions for use" carefully from the package insert that comes with the injection.
- Do not administer the injection if you have not been trained and are not sure about the administration procedure.
Interaction with other drugs:
- Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products.
FAQ:
- Q: What is the difference between Imupeg 6mg Injection pre-filled syringe and on-body injector?
- A: The on-body injector is a small, lightweight delivery system applied to the skin during your chemo appointment. It is automatically designed to inject the dose under your skin (subcutaneously) whereas the pre-filled syringe contains the Imupeg 6mg Injection medicine, and it should be injected by your healthcare provider or you manually.
- Q: What are the symptoms that I should notify the physician when taking Imupeg 6mg Injection?
- A: Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes.
- Q: What is the Imupeg 6mg Injection package insert?
- A: The FDA provides a package insert, which summarizes the relevant scientific information needed for healthcare practitioners and patients to use the drug safely and effectively. The package insert contains safety information, instructions for use, and other information.
- Q: Who should not take Imupeg 6mg Injection?
- A: Imupeg 6mg Injection is not indicated for everyone. Do not take this injection if you are allergic to pegfilgrastim, filgrastim, or any of the other ingredients in this injection.
- Q: Will Imupeg 6mg Injection affect my kidneys?
- A: This injection may affect your kidneys. Regular kidney function tests will be taken to monitor your kidney functions. Inform your physician if you have any kidney problems.
- Q: Can I breastfeed while taking Imupeg 6mg Injection?
- A: No, this injection secretes in small amounts in breast milk. Imupeg 6mg Injection can cause harm to your baby. Please consult your doctor if you are breastfeeding.
Fact box:
- Molecule name: Pegfilgrastim.
- Therapeutic class: Hematopoietic.
- Pharmacological class: Colony-stimulating factors.
- Indications: Febrile neutropenia.