Prevention of infections after chemotherapy due to decreased white blood cells (neutropenia).
Treatment for people with acute myeloid leukemia to increase the number of white blood cells and reduce fever duration.
Use in people undergoing bone marrow transplants.
Treatment for severe chronic neutropenia (low number of neutrophils in the blood).
Preparation of blood for leukapheresis (a treatment in which certain blood cells are removed from the blood).
Increase the chance of survival in people exposed to harmful amounts of radiation.
Reduction of infection risk in patients with advanced HIV infection.
Therapeutic Effects
Grastim 300mcg injection is a colony-stimulating factor that acts on blood-forming cells by binding to specific cell surface receptors, thereby inducing cell division, multiplication, and cell functional activation.
Interaction with Other Drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Grastim 300mcg injection and reduce effectiveness by causing undesirable side effects.
More Information
Store Grastim 300mcg injection in a refrigerator (2°C – 8°C). Do not freeze.
Do not shake the pre-filled syringe.
Discard the medicine if stored at room temperature for more than 48 hours.
Keep it out of reach from children and pets.
It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor immediately for advice.
How to Consume
Grastim 300mcg injection is available as a prefilled syringe. A qualified healthcare professional will administer the injection in the fatty tissues just under your skin (subcutaneously) or it will be administered as an intravenous injection into your vein slowly. The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors.
If your physician decides that you or your caregiver can administer the Grastim 300mcg injection at home, then read the “Instructions for use” carefully from the package insert with the medicine. Your doctor or other healthcare professionals will train you on self-administration. Do not administer the medicine if you have not been trained and are not sure about the administration procedure.
Safety Advices
Pregnancy: Grastim 300mcg injection is unsafe when administered during pregnancy because it may cause birth defects in your baby. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Breastfeeding: It is unsafe to breastfeed during the treatment with this Grastim 300mcg injection because it may cause harm to the baby. Please consult your doctor before breastfeeding.
Lungs: It is unknown whether Grastim 300mcg injection can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Liver: It is unknown whether Grastim 300mcg injection can be administered in patients with liver disorders. Inform your physician if you have any liver problems before starting treatment with this Injection.
Alcohol: It is unsafe to consume alcohol with Grastim 300mcg injection. Please consult your doctor for more advice.
Driving: It is unsafe to travel, drive vehicles, or operate heavy machinery after taking (1 hour) Grastim 300mcg injection. Please consult your doctor.
Side Effects
Common:
Pain in the bones, joints, and muscles
Pain at the site of injection
Fever
Itchiness and skin rash
Nausea
Headaches
Dizziness and tiredness
Nose bleeding
Hair fall
Serious:
Inflammation of Aorta
Capillary leak syndrome (plasma leaks out of tiny blood vessels)
Hypersensitivity reactions
Changes in urine color
Swelling in hands, feet, face, and abdomen
Difficulty in breathing
Sickle cell anemia
Word of Advice
Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes. If you use the prefilled syringe, allow the medicine to warm for 30 minutes at room temperature before injecting. Read the package insert carefully if you are self-administering the medicine. This medicine may cause lung, liver, or kidney problems. Your physician may advise you to take laboratory tests regularly to monitor the effectiveness of the therapy.
FAQs
What are the symptoms that I should notify the physician while taking Grastim 300mcg injection?
Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes.
What is the Grastim 300mcg injection package insert?
The FDA provides a package insert, which summarizes the relevant scientific information needed for healthcare practitioners and patients to use the drug safely and effectively. The package insert contains safety information, instruction for use, and other information.
Who should not take Grastim 300mcg injection?
Grastim 300mcg injection is not indicated for everyone. Do not take this medicine if you are allergic to any forms of rubber, latex, pegfilgrastim, filgrastim or any of the other ingredients in this medicine.
Will Grastim 300mcg injection affect my kidneys?
This medicine may affect your kidneys. Regular kidney function tests will be taken to monitor your kidney functions. Inform your physician if you have any kidney problems.
Can I breastfeed while taking Grastim 300mcg injection?
No, this medicine secretes in small amounts in breast milk. Grastim 300mcg injection can cause harm to your baby. Please consult your doctor if you are breastfeeding.
