Systemic mastocytosis with associated hematological neoplasm (SM-AHN)
Mast cell leukemia (MCL)
Important Safety Information
Allergies: Do not take if allergic to midostaurin or any other ingredients.
Infections: Inform your healthcare professional if you have any symptoms of an infection.
Heart and lung disorders: Inform your healthcare professional if you have any heart or lung problems.
Pregnancy and breastfeeding: Not recommended for pregnant or breastfeeding women. Discuss with your doctor if planning pregnancy.
Children and adolescents: Not recommended for children and adolescents below 18 years of age.
Fertility: May reduce fertility in men and women; discuss this with your doctor before starting therapy.
Missed dose: If you miss a dosage, take it as soon as you remember. If it is almost time for the next dose, skip the missing dose. Do not take a double dose to compensate for a missed dose.
Side Effects
Common side effects:
Swelling in the lower limbs
Skin rash
Increased blood sugar levels
Abdominal pain
Constipation, diarrhea
Nausea, vomiting
Musculoskeletal pain
Headache
Bleeding from nose
Upper respiratory infection
Tiredness
Fever
Serious side effects:
Heart failure
GI bleeding
Fever with decreased blood cell counts
Hypersensitivity reactions
Kidney problems
Pneumonia
Blood infection
Driving and Alcohol
Driving vehicles or operating machinery after taking Mistaurin 25mg capsule is unsafe as you may develop dizziness and vertigo.
It is unsafe to consume alcohol when taking Mistaurin 25mg capsule because it may cause alcohol-related problems, epilepsy, or liver problems.
Interaction with Other Drugs
Inform your healthcare provider about all the medicines you are taking, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products.
Storage
Store Mistaurin 25mg capsule at room temperature (25°C).
Keep the capsule away from the reach of children and pets.
How to Consume
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors.
Take the Mistaurin 25mg capsule as prescribed by your doctor. Do not open, break, crush, or chew the capsules. Swallow the capsule whole with a glass of water.
Take the capsules with food at the same time each day.
FAQs
Q 1. What are the cautions of Mistaurin 25mg capsule?
Tell your doctor immediately if you start to have swelling of your face, lower limbs or skin, fever, sore throat, mouth ulcers, cough with or without mucous, chest pain or discomfort, trouble breathing, shortness of breath, light-headedness, fainting, dizziness, blue discoloration of your lips, hands or feet.
Q 2. Can Mistaurin 25mg capsule cause vomiting?
Yes, Mistaurin 25mg capsule has a moderate emetic effect and can cause vomiting. Do not take an extra capsule if you have vomited after taking your first dose.
Q 3. Does Mistaurin 25mg capsule cause hair loss?
No, hair loss is not a side effect of Mistaurin 25mg capsule. Hair loss can happen due to cancer itself. Consult your doctor if you have excessive hair loss.
Q 4. How will I be monitored during the treatment with Mistaurin 25mg capsule?
Your doctor will perform regular blood tests during treatment with Mistaurin 25mg capsule in order to monitor the number of blood cells (white blood cells, red blood cells, and platelets) and electrolytes such as calcium, potassium, and magnesium in your body. Your heart and lung function will also be checked regularly.
Q 5. How long does it take Mistaurin 25mg capsule to work?
Mistaurin 25mg capsule is a long-term treatment. Most people who benefit from this treatment will notice an improvement in the first 12 weeks of starting treatment.
Q 6. What will happen if I stop taking Mistaurin 25mg capsule suddenly?
Stopping your treatment suddenly may cause your condition to become worse. Do not stop taking your medicine without consulting your doctor.
Fact Box of Mistaurin 25mg Capsule
Molecule name: Midostaurin
Therapeutic class: Antineoplastics
Pharmacological class: Tyrosine kinase inhibitor
Indications:
Acute myeloid leukemia (AML)
Aggressive systemic mastocytosis (ASM)
Systemic mastocytosis with associated hematological neoplasm (SM-AHN)