Contains the active compound enzalutamide, which belongs to the class of medications called androgen receptor inhibitors.
Used to treat men with prostate cancer, particularly in cases where other treatments (hormonal therapy or testosterone-lowering surgery) no longer effectively control the malignancy.
Suitable for treatment in metastatic cases where the cancer has spread from the prostate to other parts and reacts to hormone therapy or surgery to reduce testosterone levels.
Also used in cases of prostate cancer that is responsive to castration (surgical removal of testicles) but is not metastatic, with a high chance of metastasis and a biochemical recurrence.
Uses
Prostate cancer resistant to other treatments.
Metastatic prostate cancer that reacts to hormone therapy or surgery to reduce testosterone levels.
Non-metastatic prostate cancer with a high chance of spread and recurrence.
Therapeutic Effects
Blocks the activity of androgen hormones (such as testosterone) by binding with androgen receptors.
Prevents the androgen receptor from moving to its new site, which further lowers AR-mediated transcriptional activity and stops the growth of tumor cells.
Inhibits the AR complex's ability to bind to DNA, which stops the transcriptional activation of AR target genes.
Reduces testosterone levels and halts the growth and division of prostate cancer cells.
Interaction with Other Drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products.
Certain medications may interact with Enzabuzz 40mg Capsule and reduce effectiveness by causing undesirable side effects.
More Information
Store at room temperature between 20°C and 25°C (68°F and 77°F).
Keep dry and protected from light and moisture.
Keep the capsules in the original container with the cap tightly closed.
Keep out of reach from children and pets.
It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.
How to Consume
Usually taken orally, with or without food.
Swallow the capsules whole with a glass of water and not crushed, chewed or broken.
The dosage and frequency will depend on various factors, including the patient's age, weight, overall health, and the type and stage of cancer being treated.
Follow the dosing instructions provided by a healthcare provider.
Safety Advices
Pregnancy
Not indicated for use in women.
Unsafe for pregnant women as it may cause foetal harm.
Effective contraception is important.
Breast Feeding
Not recommended during breastfeeding, as it is unknown if it is excreted in human milk.
Lungs
Unknown whether Enzabuzz 40mg Capsule is safe for patients with lung problems.
Inform your physician if you have any lung disease before starting the treatment.
Liver
Inform your physician about any underlying liver disorders before taking Enzabuzz 40mg Capsule.
Alcohol
Typically advised that patients taking Enzabuzz 40mg Capsule avoid or consume alcohol in moderation.
Driving
Enzabuzz 40mg Capsule may cause side effects such as seizures, dizziness, or blurred vision that can impair a patient's ability to drive or operate machinery safely.
Side Effects
Common: tiredness, fall, hot flushes, high blood pressure, headache, feeling anxious, dry skin, itching, difficulty in remembering, restlessness.
Serious: posterior reversible encephalopathy syndrome (PRES), blockage of the arteries (ischemic heart disease), enlargement of breast in men (gynaecomastia), broken bones.
Word of Advice
Follow the instructions provided by your healthcare provider and report any side effects or concerns promptly.
Do not consume grape juice during the treatment.
Stay hydrated by consuming lots of liquids, particularly if you get diarrhea when using Enzabuzz 40mg Capsule.
Attend all scheduled appointments and follow-up visits with your healthcare provider.
FAQs
Can I take Enzabuzz 40mg Capsule if I have a liver problem?
It is not recommended for liver patients; speak with your doctor before using the Enzabuzz 40mg Capsule if you have any liver problems.
Can I take Enzabuzz 40mg Capsule if I am pregnant?
No, Enzabuzz 40mg Capsule is not recommended for pregnant women. It may be contraindicated for pregnant women, and it might cause harm to the foetus.
Should I monitor any parameters while taking Enzabuzz 40mg Capsule?
Your doctor will advise you to check your blood pressure and hemoglobin level and bone density because Enzabuzz 40mg Capsule may cause low blood pressure and anemia as a side effect.
What are the precautions I need to take while taking Enzabuzz 40mg Capsule?
Inform your doctor if you have any history of liver, kidney or heart problem (irregular heart beat) and seizure or cancer (other than prostate cancer).
Inform your doctor if you have gastrointestinal problems or blood in urine or frequent urge for urination.
Can I take Enzabuzz 40mg Capsule if I have a seizure?
No, it is not recommended for patients with seizures. It may be contraindicated for a person with seizure.
Indications: Prostate cancer resistant to other treatments, metastatic prostate cancer reacts to hormone therapy or surgery to reduce testosterone levels, non-metastatic prostate cancer with a high chance of spread and recurrence.