An anticancer medicine consisting of the active ingredient Bevacizumab.
Developed to prevent the growth of tumors.
Indicated along with other chemotherapy drugs to treat metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer.
Also used to treat cancers of the ovary, fallopian tube, or primary peritoneal cancer.
Uses:
Glioblastoma multiforme (brain cancer).
Persistent, recurrent, or metastatic breast cancer.
Metastatic cervical cancer.
Advanced kidney cancer.
Metastatic colorectal cancer.
Advanced non-small-cell lung cancer.
Liver cancer — Hepatocellular carcinoma.
Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer.
Therapeutic Effects:
A recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers.
Produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), present in the lining of blood and lymph vessels in the body.
Interrupts the interaction of VEGF-A with its receptors, inhibiting the formation of blood vessels that supply oxygen and nutrients to the tumor.
Slows down the rate of progression of cancer.
Interaction with Other Drugs:
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment.
Certain medications may interact with Bryxta 400mg Injection and cause undesirable side effects.
Safety Advices:
Pregnancy: Inform your physician before starting treatment with Bryxta 400mg Injection if you are pregnant or planning for pregnancy.
Breastfeeding: Avoid breastfeeding for a minimum of 6 months after treatment with Bryxta 400mg Injection.
Lungs: Inform your doctor if you have any lung conditions before starting treatment.
Liver: Inform your physician before starting Bryxta 400mg Injection if you have liver diseases.
Alcohol: Consult your doctor to know if it is safe to consume alcohol while on treatment with Bryxta 400mg Injection.
Driving: Avoid driving or using machinery while on treatment with Bryxta 400mg Injection as it may cause dizziness or sleepiness.
Side Effects:
Serious: Headache, vision changes, confusion, severe allergic reactions, high blood pressure, delayed wound healing following surgery, protein in urine, severe infections, blood clots in arteries and blood vessels of lungs, gut perforation, nosebleeds and bleeding risk, heart problems with an increase in heart rate, mouth sores, dryness, shortness of breath.
Common: Numbness in hands or feet, weakness and lack of energy, diarrhea, nausea, vomiting, abdominal pain, constipation, loss of appetite, weight loss, changes in taste and speech, decrease in counts of white blood cells, fever, dry skin, back pain.
Administration:
Administered intravenously through infusion.
The amount of drug will be measured based on the patient’s body weight, height, and age.
The first dose will be administered for 90 minutes, and if well tolerated, the infusion time can be reduced to 30 minutes.
Storage:
Store Bryxta 400mg Injection at 2˚C to 8˚C.
Do not freeze or shake.
Protect from light.
Keep out of reach of children.
FAQs:
Is Bryxta 400mg Injection used as standalone treatment in cancers?
Bryxta 400mg Injection can be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.
Is it safe for women to use Bryxta 400mg Injection?
Women with reproductive potential should discuss effective birth control methods with their doctor during treatment and for at least 6 months after the last dose.
Is it safe to undergo surgery during the treatment with Bryxta 400mg Injection?
Avoid planning for surgery and maintain an interval of 28 days before or after surgery as Bryxta 400mg Injection is associated with increased risk of bleeding complications and poor wound healing.
Do the side effects of Bryxta 400mg Injection last for a chronic period?
Side effects occur until the drug concentration stays in the body. Bryxta 400mg Injection will be contained in the body for almost 4 months after the final dose.
How is Bryxta 400mg Injection administered?
Bryxta 400mg Injection is given intravenously through infusion. The amount of drug will be measured based on the patient’s body weight, height, and age. The first dose will be administered for 90 minutes, and if well tolerated, the infusion time can be reduced to 30 minutes.
Can I take Bryxta 400mg Injection if I am pregnant?
Inform your physician before starting treatment with Bryxta 400mg Injection if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby.
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