Persistent, recurrent, or metastatic breast cancer;
Metastatic cervical cancer;
Advanced kidney cancer;
Metastatic colorectal cancer;
Advanced non-small-cell lung cancer;
Liver cancer — hepatocellular carcinoma;
Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer.
Mechanism of action:
Bevacirel 400mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers.
It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), present in the lining of blood and lymph vessels in the body.
This interrupts the interaction of VEGF-A with its receptors, inhibiting the formation of blood vessels that supply oxygen and nutrients to the tumor.
As a result, it slows down the rate of progression of cancer.
Administration:
Bevacirel 400mg Injection is administered intravenously through infusion.
The amount of drug will be measured based on the patient’s body weight, height, and age.
The first dose will be administered for 90 minutes, and if well tolerated, the infusion time can be reduced to 30 minutes.
Safety advice:
Pregnancy: inform your physician before starting treatment with Bevacirel 400mg Injection if you are pregnant or planning for pregnancy.
Breastfeeding: it is recommended to avoid breastfeeding for a minimum of 6 months after your treatment with Bevacirel 400mg Injection.
Lungs: inform your doctor if you have any lung conditions before starting treatment.
Liver: inform your physician before starting Bevacirel 400mg Injection if you have liver diseases.
Alcohol: consult your doctor to know if it is safe to consume while you are on treatment.
Driving: avoid driving or using machinery while you are on treatment as it is related to causing dizziness or sleepiness.
Side effects:
Serious: headache, vision changes, confusion, severe allergic reactions, high blood pressure, delayed wound healing following surgery, protein in urine, severe infections, blood clots in arteries and blood vessels of lungs, gut perforation, nosebleeds and bleeding risk, heart problems with an increase in heart rate, mouth sores, dryness, shortness of breath.
Common: numbness in hands or feet, weakness and lack of energy, diarrhoea, nausea, vomiting, abdominal pain, constipation, loss of appetite, weight loss, changes in taste and speech, decrease in counts of white blood cells, fever, dry skin, back pain.
Interaction with other drugs:
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment.
Storage:
Store Bevacirel 400mg Injection at 2˚C to 8˚C. Do not freeze or shake.
Protect from light. Keep out of reach of children.
FAQs:
Is Bevacirel 400mg Injection used as standalone treatment in cancers?
Bevacirel 400mg Injection is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.
Is it safe for women to use Bevacirel 400mg Injection?
While for women with reproductive potential subjected to Bevacirel 400mg Injection, it is advised to discuss with your doctor regarding the effective birth control methods during the treatment. Also, to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.
Is it safe to undergo surgery during the treatment with Bevacirel 400mg Injection?
Bevacirel 400mg Injection is associated with an increased risk of bleeding complications and poor wound healing. Hence, it is suggested to avoid planning for surgery and maintain an interval of 28 days before or after surgery.
Do the side effects of Bevacirel 400mg Injection last for a chronic period?
All the side effects that are relatively caused by Bevacirel 400mg Injection occur until the drug concentration stays in the body. It is found that this medicine will be contained in our body for almost 4 months after the final dose.
How is Bevacirel 400mg Injection administered?
Bevacirel 400mg Injection is given intravenously through infusion, and the amount of drug will be measured based on the patient’s body weight, height, and age. The first dose will be administered for 90 minutes, and if well tolerated, the infusion time can be reduced to 30 minutes.
Can I take Bevacirel 400mg Injection if I am pregnant?
Inform your physician before starting your treatment with Bevacirel 400mg Injection in case, if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.
