Treatment of Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant.
Intermediate-2 and High-risk Myelodysplastic syndrome (MDS).
Therapeutic Effects:
In MDS and AML, the development of tumor cells is caused by transcriptional repression of various genes due to the hypermethylation of DNA.
The active form of Azacitidine binds to RNA and DNA, interrupts their activity in actively multiplying cells, and exhibits a toxic effect on cancer cells.
Interaction with other drugs:
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment.
Certain medications may interact with Azacitidine and cause undesirable side effects.
Storage:
Store at room temperature (15-30°C).
If the product is reconstituted, it must be used immediately; if not, store at 2-8°C for not more than 8 hours.
Keep the injection out of sight and reach of children.
How to consume:
Take Azacitidine only under the supervision of your physician.
Your physician will decide the dose based on your height, weight, and general condition.
It shall be given under the skin of your thigh, stomach, or upper arm.
Safety Advices:
Pregnancy: Azacitidine could be harmful to the unborn fetus. Inform your physician if you are pregnant or planning to get pregnant.
Breastfeeding: Breastfeeding is not intended for patients on Azacitidine therapy. Consult your physician for advice.
Lungs: It is not known whether it is safe to administer Azacitidine in lung failure patients. Please consult your doctor.
Liver: Inform your physician if you have been told that you have a tumor in the liver cells.
Alcohol: It is not known whether it is safe to consume alcohol with Azacitidine. Please consult your doctor.
Driving: It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking Azacitidine.
Side Effects:
Serious: unexpected bleeding, fever, pneumonia, allergic reaction, seizures, loss of consciousness, severe headache, or bleeding in the brain, frequent urination with pain or burning sensation.
Common: disturbances in the blood count (RBC, WBC, Platelets), nausea, vomiting, diarrhea, constipation, tiredness, decreased appetite, rashes, redness of the skin, dizziness, joint pain, headache, sore throat, and nose.
Word of Advice:
Inform the doctor if the patient has any allergy reactions, respiratory problems, kidney, liver, or heart problems, and medication taken for different medical conditions before taking this injection as they worsen the condition.
Avoid using this injection if the patient is planning for pregnancy or during pregnancy and in breastfeeding mothers as this medicine causes harmful effects in the developing baby.
FAQs:
How to use Azacitidine 100mg Injection?
Take Azacitidine 100mg Injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. Azacitidine 100mg Injection is administered under the skin of your thigh, stomach, or upper arm.
Does Azacitidine 100mg Injection cause hair loss?
No, Azacitidine 100mg Injection does not cause hair loss even after using it for a prolonged period of time.
How does Azacitidine 100mg Injection work?
Azacitidine 100mg Injection binds to RNA and DNA, interrupts their activity in actively multiplying cells, and exhibits a toxic effect on cancer cells.
Is Azacitidine 100mg Injection chemotherapy?
Yes. Azacitidine 100mg Injection is chemotherapy used in the treatment of cancers. It interferes with the cell's DNA synthesis and decreases growth and multiplication (cytotoxic effect).
What are the side effects of Azacitidine 100mg Injection?
The common side effects of Azacitidine 100mg Injection are nausea, vomiting, diarrhea, constipation, tiredness, decreased appetite, rashes, redness of the skin, dizziness, joint pain, headache, sore throat, and nose.
Is it safe to drive after taking a Azacitidine 100mg Injection?
It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking this medication.
Fact Box:
Molecule name: Azacitidine.
Therapeutic class: Anti-metabolites.
Pharmacological class: Anti-Neoplastics.
Indications:
Treat advanced or metastatic non-small lung cancer (NSCLC).
