Azafab 100mg Injection for injection is used for treating adults with Myelodysplastic syndrome (MDS) and Acute myeloid leukemia (AML) if they are considered ineligible for stem cell transplant. In Myelodysplastic Syndrome, the bone marrow does not produce healthy blood cells due to its lack of function. Acute Myeloid Leukemia is a type of bone marrow cancer that is caused by the release of incompletely formed blood cells into the bloodstream.
Uses of Azafab 100mg Injection
Treatment of Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant
Intermediate-2 and High-risk Myelodysplastic syndrome (MDS)
Therapeutic Effects of Azafab 100mg Injection
In MDS and AML, the development of tumor cells is caused by the process of transcriptional repression of various genes, which is due to hypermethylation of DNA. Transcriptional repression is a process where proteins bind directly or indirectly to DNA and control the activity of copying a specific gene or a set of genes. The active form of Azafab 100mg Injection binds to RNA and DNA, interrupts their activity in actively multiplying cells and exhibits a toxic effect on cancer cells. Interaction of Azafab 100mg Injection with other drugsInform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with azafab 100 mg injection and cause undesirable side effects.More Information about Azafab 100mg Injection Store at room temperature (15-30°C). If the product is reconstituted, it must be used immediately; if not, store at 2-8°C for not more than 8 hours. Keep the injection out of sight and reach of children.How to consume Azafab 100mg InjectionTake Azafab 100 mg Injection only under the supervision of your physician. Your physician will decide the dose based on your height, weight, and general condition. Azafab 100mg Injection shall be given under the skin of your thigh, stomach, or upper arm.Safety Advices for Azafab 100mg Injection
Pregnancy
Azafab 100mg Injection could be harmful to the unborn fetus. Inform your physician if you are pregnant or planning to get pregnant.
Breast Feeding
Breastfeeding is not intended for patients on Azafab 100mg Injection therapy. Consult your physician for advice.
Lungs
It is not known whether it is safe to administer Azafab 100 mg Injection in lung failure patients. Please consult your doctor.
Liver
Inform your physician if you have been told that you have a tumor in the liver cells.
Alcohol
It is not known whether it is safe to consume alcohol with Azafab 100mg Injection. Please consult your doctor.
Driving
It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking Azafab 100 mg injection.
Side Effects of Azafab 100mg InjectionSide effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
Unexpected bleeding, with blood in stool and urine
Fever
Pneumonia, characterized by chest pain or breathlessness.
Allergic reaction with symptoms of swelling of lips, itching or rashes.
Seizures, loss of consciousness, severe headache or bleeding in the brain
Frequent urination with pain or burning sensation
Common:
Disturbances in the blood count (RBC, WBC, Platelets)
Nausea, vomiting, diarrhea
Constipation
Tiredness
Skin reactions like redness and pain at the site of injection
Decreased appetite
Dizziness
Pain in extremities
Joint pain
Stomach pain
Headache
Sore nose and throat
Rashes and bruising
Word of AdviceInform the doctor if the patient has any allergy reactions, respiratory problems, kidney, liver, or heart problems, and medication taken for different medical conditions before taking this injection as they worsen the condition. Avoid using this injection if the patient is planning for pregnancy or during pregnancy and in breastfeeding mothers as this medicine causes harmful effects on the developing baby. Take this injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. It is administered under the skin of your thigh, stomach, or upper arm.FAQs Q 1. How to use Azafab 100mg Injection?
Take Azafab 100mg Injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. Azafab 100mg Injection is administered under the skin of your thigh, stomach or upper arm.
Q 2. Does Azafab 100mg Injection cause hair loss?
No, Azafab 100mg Injection does not cause hair loss even after using it for a prolonged period of time.
Q 3. How does Azafab 100mg Injection work?
Azafab 100mg Injection binds to RNA and DNA, interrupts their activity in actively multiplying cells and exhibits a toxic effect on cancer cells.
Q 4. Is Azafab 100mg Injection chemotherapy?
Yes. Azafab 100mg Injection is chemotherapy and it is used in the treatment of cancers. It interferes with the cell's DNA synthesis and decreases growth and multiplication (cytotoxic effect).
Q 5. What are the side effects of Azafab 100mg Injection?
The common side effects of Azafab 100mg Injection are Nausea, vomiting, diarrhea, constipation, tiredness, decreased appetite, rashes, redness of skin, dizziness, joint pain, headache, sore throat and nose.
Q 6. Is it safe to drive after taking an Azafab 100mg Injection?
It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking Azafab 100 mg injection.
Fact Box of Azafab 100mg Injection
Molecule name: Azacitidine
Therapeutic class: Anti-metabolites
Pharmacological class: Anti-Neoplastics
Indications:
1. Treat advanced or metastatic non-small lung cancer (NSCLC),
2. To Treat Advanced or metastatic pancreatic cancer.
Основные характеристики
Manufacturer
MANKIND PHARMACEUTICALS LIMITED
Origin of Medicine
India
Price for
1 Vial(s)
Salt Composition
Azacitidine
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