Knilonat 150mg capsule is an antineoplastic drug with an active ingredient called Nilotinib. It belongs to the medication class known as tyrosine kinase inhibitors. This medicine is used to treat a type of leukemia called Philadelphia chromosome-positive chronic myeloid leukemia (Ph-positive CML), a blood cancer with abnormal production of WBC. In adult and pediatric patients, it is used in a patient who is newly diagnosed with Chronic Myeloid Leukemia (CML) and those facing side effects from previous treatment. Additionally, it is also used in patients with no longer respond to the previous treatment including Imatinib.
Do not take this medicine if you are allergic to Nilotinib or the other ingredients of this medicine. Notify your doctor if you have or had a history of heart conditions (heart attack, abnormal electric signal), chest pain, brain stroke, or claudication ( condition of blood flow in the leg). Inform your doctor if you have liver or pancreas disorder, or suffering from a lack of potassium or magnesium. You need to tell your doctor about all the medications especially if you take medicine to lower your blood cholesterol. Tell your doctor about your underlying condition especially inform about if you have or ever had a hepatitis B infection; this medicine can activate HPV again which can be fatal in some cases. Avoid consuming grapefruit or grapefruit juice. Inform your doctor if you are intolerant to some sugar, as this medicine contains lactose.
During the treatment, your doctor may conduct a regular blood test to monitor the liver and pancreas function, and the number of blood cells (WBC, RBC, platelets). Also to monitor the heart condition (prolongation of the QT interval), electrolytes in the body, and the level of sugar and fats to check how Knilonat 150mg capsule is tolerated. Inform your doctor if you are pregnant or planning to get pregnant or breastfeeding. Use effective birth control during the treatment with this medicine.
Uses of Knilonat 150mg CapsuleBlood cancer (Philadelphia chromosome-positive chronic myeloid leukemia) in adults and pediatrics. Therapeutic Effects of Knilonat 150mg Capsule
BCR-ABL tyrosine kinase is responsible for the uncontrolled division of cells in the CML. Knilonat 150mg capsule disrupts the signaling route of the protein kinase enzyme which targets the BCR-ABL protein and inhibits the growth and spread of cancer cells. Interaction of Knilonat 150mg Capsule with other drugsInform your healthcare professional about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, and herbal products. Certain medications such as antiarrhythmics, chloroquine, Titonavir, Carbamazepine, or any other drugs, interacting with Knilonat 150mg capsule may reduce effectiveness by causing undesirable side effects.More Information about Knilonat 150mg Capsule Keep this medicine out of the sight and reach of children and petsDo not store above 30°CKeep it in its original packaging in order to protect it from light and moisture.How to consume Knilonat 150mg CapsuleTake Knilonat 150mg capsule as advised by your physician. Swallow the medicine with a glass of water. Do not crush, chew, or open the medicine. Your doctor will decide the correct dose and duration for you based on your age, body weight, and disease condition. Do not stop taking Knilonat 150mg capsule unless your doctor advises you to stop.Safety Advices for Knilonat 150mg Capsule
Pregnancy
Knilonat 150mg capsule is unsafe to use during pregnancy unless it is necessary. Report to your doctor if you are pregnant or think you may be pregnant, or planning for the pregnancy before starting the treatment; your doctor will tell you whether you can take this medicine during your pregnancy.
Breast Feeding
Taking Knilonat 150mg capsule while breastfeeding may be unsafe because it may affect the child. Therefore, talk with your doctor to get more information.
Lungs
It is unknown if patients with lung conditions can consume Knilonat 150mg capsule. So, before beginning the treatment, consult your doctor if you have any lung conditions. Consult your doctor if you experience symptoms like difficulty in breathing, wheezing or any other lung related condition while taking Knilonat 150mg capsule.
Liver
Inform your physician if you have liver problems because Knilonat 150mg capsule should be used cautiously with this condition. Before starting treatment, your physician conduct the liver function test.
Alcohol
It is unknown whether consuming alcohol while taking a Knilonat 150mg capsule is safe. Please speak with your physician.
Driving
While taking Knilonat 150mg capsule, it is unsafe to drive or use machines because it may cause nausea, changes in vision, vomiting, etc. Talk to your doctor for more information.
Side Effects of Knilonat 150mg CapsuleSide effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Serious
- Sudden weight gain
- Swelling in hands, feet, ankles, or face
- Chest pain
- Blood pressure (high and low)
- Discoloration of tongue, lips, or skin (blue)
- Abnormal heart (irregular heartbeat)
- Hair loss
- Vision problem
- Stomach pain, vomiting of blood, blood in stools.
- Yellowing of the skin, eyes, and dark urine.
- High blood sugar levels.
- Sensitivity to light
Common:
- Nausea, vomiting, diarrhoea.
- Headache, muscle pain, stomach pain.
- Hair loss.
- Tiredness.
- Constipation.
- Slowing growth in children.
- Pneumonia.
- Loss of appetite.
- Sleeplessness, depression, and anxiety.
- Stomach discomforts like bloating and flatulence after meals.
- musculoskeletal pain
Word of AdviceBased on your condition your doctor may prescribe a lower dose. Knilonat 150mg capsule can be used by people aged 65 years and over with the same dose as other adults. Tell your doctor if you experience any irregular heartbeats or any signs of a heart condition because this can lead to serious complications like sudden death. Inform your physician if you have kidney problems. Your physician will decide whether you may receive this medication after monitoring your kidney functions. Some children and adolescents taking this medicine may have slower than normal growth. So, your doctor will regularly monitor your growth. Report to your doctor if you have had a history of heart failure or hepatitis infection. Discuss effective contraceptive options with your healthcare provider.FAQs Q 1. Can Knilonat 150mg capsule cause liver damage?Knilonat 150mg capsule may cause liver function abnormalities, which may indicate liver damage. It is important to have regular blood tests to monitor your liver function while taking Knilonat 150mg capsule. If you experience symptoms of liver damage, such as jaundice or abdominal pain, you should contact your doctor immediately.
Q 2. How does Knilonat 150mg capsule differ from other medications used to treat chronic myeloid leukemia, such as Imatinib?Imatinib, in its selectivity and potency. Knilonat 150mg capsule is more selective for the BCR-ABL protein that drives the growth of cancer cells, and it is more potent in inhibiting the activity of this protein. Knilonat 150mg capsule has also been shown to be effective in patients who have developed resistance to Imatinib
Q 3. What are the potential long-term effects of Knilonat 150mg capsule on the body?The potential long-term effects of Knilonat 150mg capsule on the body include cardiovascular events, such as hypertension, arrhythmias, and heart failure, as well as liver dysfunction, pancreatic enzyme elevation, and fluid retention. These side effects are generally rare, but they can occur in some patients.
Q 4. How to monitor the effects of Knilonat 150mg capsule over the course of treatment?It is monitored through regular blood tests, electrocardiograms, and imaging studies. Blood tests can assess liver and kidney function, blood counts, and electrolyte levels. ECG can detect any changes in heart rhythm or function. Imaging studies, such as echocardiograms and chest X-rays, can evaluate the heart and lungs for any signs of damage or fluid accumulation.
Q 5. Who should not take Knilonat 150mg capsule?Knilonat 150mg capsule should not be taken by pregnant or breastfeeding women, or by people with certain medical conditions such as severe liver or kidney disease, a history of pancreatitis, or a prolonged QT interval.
Fact Box of Knilonat 150mg CapsuleMolecule name: Nilotinib | Therapeutic class: Antineoplastic drug |
Pharmacological class: Tyrosine Kinase inhibitors | Indications: Blood cancer (Philadelphia chromosome-positive chronic myeloid leukemia) in adults and pediatrics. |
